Figure 2.

Cumulative incidence per 100,000 hypothetical women of proximal colon cancer (A) and distal colon cancer (B) for a never smoker versus a current smoker (30 pack-years by age 30 years and 1 pack/day from ages 30–70 years), based on data from the Nurses’ Health Study, 1980–2010. Unless otherwise specified, all women were assumed at baseline to be aged 50 years, have no family history of colon or rectal cancer in a first-degree relative, consume 1 serving per day of red meat, consume no processed meat, consume 400 µg/day of folate, have a body mass index (weight (kg)/height (m)²) of 26, perform 15 metabolic equivalent hours/week of physical activity, have a height of 64.5 inches, consume no alcohol, use no aspirin, have had no screening endoscopy, have used no postmenopausal hormone, and consume 1,000 mg/day of calcium.