Table 4.
Association of Accelerometer-Measured Sedentary Time With Leukocyte Telomere Length Among Older Women, by Hours/Day of Accelerometer-Measured Moderate- to Vigorous-Intensity Physical Activity, Women's Health Initiative OPACH Study, 2012–2013
| MVPA Time and Model | Quartile of Accelerometer-Measured Sedentary Time, hours/day | Ptrenda | ||||||
|---|---|---|---|---|---|---|---|---|
| <8.18 (Referent) | 8.18–9.23 | 9.24–10.21 | ≥10.22 | |||||
| βb | 95% CI | β | 95% CI | β | 95% CI | |||
| ≤0.69 hours/day | ||||||||
| 1c | 0 | −0.03 | −0.19, 0.13 | −0.16 | −0.32, −0.002 | −0.21 | −0.38, −0.05 | <0.01 |
| 2d | 0 | −0.03 | −0.18, 0.12 | −0.14 | −0.29, 0.01 | −0.16 | −0.31, −0.002 | 0.03 |
| 3e | 0 | −0.06 | −0.21, 0.09 | −0.17 | −0.32, −0.02 | −0.19 | −0.35, −0.03 | 0.02 |
| 4f | 0 | −0.05 | −0.21, 0.10 | −0.16 | −0.32, −0.01 | −0.19 | −0.35, −0.03 | 0.02 |
| 5g | 0 | −0.04 | −0.20, 0.11 | −0.15 | −0.31, 0.01 | −0.17 | −0.34, −0.004 | 0.25 |
| >0.69 hours/day | ||||||||
| 1 | 0 | −0.01 | −0.13, 0.11 | −0.11 | −0.24, 0.02 | −0.11 | −0.27, 0.05 | 0.07 |
| 2 | 0 | 0.04 | −0.07, 0.14 | −0.05 | −0.17, 0.07 | −0.02 | −0.17, 0.13 | 0.45 |
| 3 | 0 | 0.04 | −0.07, 0.15 | −0.03 | −0.15, 0.09 | −0.01 | −0.16, 0.14 | 0.68 |
| 4 | 0 | 0.05 | −0.06, 0.16 | −0.02 | −0.15, 0.10 | −0.01 | −0.16, 0.15 | 0.78 |
| 5 | 0 | 0.07 | −0.05, 0.18 | −0.02 | −0.14, 0.11 | −0.02 | −0.17, 0.14 | 0.91 |
Abbreviations: CI, confidence interval; MVPA, moderate- to vigorous-intensity physical activity; OPACH, Objective Physical Activity and Cardiovascular Health.
aP values were calculated using multiple linear regression models.
b Beta coefficients represent the difference in leukocyte telomere length (in kilobases).
c Results were adjusted for hours of wear time (n = 653 for ≤0.69 hours/day; n = 644 for >0.69 hours/day).
d Results were adjusted for model 1 variables plus age and race/ethnicity (n = 653 for ≤0.69 hours/day; n = 644 for >0.69 hours/day).
e Results were adjusted for model 2 variables plus education and baseline marital status, smoking, and alcohol consumption (n = 636 for ≤0.69 hours/day; n = 634 for >0.69 hours/day).
f Results were adjusted for model 3 variables plus body mass index (n = 629 for ≤0.69 hours/day; n = 627 for >0.69 hours/day).
g Results were adjusted for model 4 variables plus history of chronic diseases and use of hormone therapy (n = 620 for ≤0.69 hours/day; n = 615 for >0.69 hours/day).