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Design and construction of a CRP single-chain dimer (CRPSC). A, model of a CRPSC that connects the two CRP subunits (cyan and orange) through a flexible polypeptide linker (red). The model was rendered in PyMOL based on the CRP structure bound to cyclic nucleotide (PDB 1G6N). B, structure of CRP in the unliganded (left, PDB 2WC2) and cAMP-bound conformations (right, PDB 1G6N). cAMP is shown in magenta.
