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. 2017 Feb 27;292(15):6123–6134. doi: 10.1074/jbc.M116.769125

Figure 7.

Figure 7.

BLT2 activation decreases zymosan-induced thermal hyperalgesia and mechanical allodynia. A, thermal thresholds after injection of 20 μl of zymosan (3 mg/ml) in one hind paw of wild-type mice. 100 μl of CAY10582 or vehicle was administered intraperitoneally at the indicated times (black arrows). The data are shows as means ± S.E. (n = 6; two-way ANOVA; Bonferroni post correction). *, p < 0.05 (comparison to vehicle); ****, p < 0.0001 (comparison to vehicle); ##, p < 0.01 (comparison between treatments). B, same as A except that mechanical paw withdrawal latencies were determined. The data are shown as means ± S.E. (n = 6; two-way ANOVA; Bonferroni post correction). *, p < 0.05; **, p < 0.01. C, thermal thresholds after injection of 20 μl of zymosan (3 mg/ml) in one hind paw of wild-type or TRPV1 knock-out mice. The data are shows as means ± S.E. (n = 6; two-way ANOVA; Bonferroni post correction). **, p < 0.01; ****, p < 0.0001. D, same as C except that mechanical thresholds were determined. Thresholds within the genotypes were compared with baseline levels using one-way ANOVA and Bonferroni post correction. *, p < 0.05; **, p < 0.001. Thresholds between the groups were compared using two-way ANOVA and Bonferroni post correction. ##, p < 0.001. E, LTB4 level in untreated or zymosan-injected paws of wild-type mice. The data are shown as means ± S.E. (n = 5; one-way ANOVA; Bonferroni post hoc test). **, p < 0.01; ***, p < 0.001. PWL, paw withdrawal latency.