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Inhibition of MK2 phosphorylation by SB203580. Down-regulation of IL-1β-induced MK2 phosphorylation by applying the inhibitor SB203580, as simulated with the model for the time point 20, and treatment with different concentrations of IL-1β. At 1.127 μm SB203580, the amount of phosphorylated MK2 is around 50% of the original amount of phosphorylated MK2 without SB203580. This does not depend on the used IL-1β concentration.
