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. 2017 Feb 24;292(15):6325–6338. doi: 10.1074/jbc.M116.754440

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Figure 6. — LigPlot+ representation of the SH3-SH3 domain contacts and PRR-SH3 interactions within the super-SH3 complex β-PIX·Itch PRR (PDB code 5SXP). A, schematic representation of the β-PIX SH3 domains facing each other as in the super-SH3 structure with residues 194–199 of the SH3′ represented as purple sticks and their corresponding SH3″ residues in green. B, LigPlot+ analysis of the SH3′-SH3″ interactions (35, 36). Hydrophobic contacts are represented by red half-circles. Cyan spheres represent water molecules establishing a water-mediated bond between both SH3 domains. Hydrogen bonds and their length are displayed in green. Residues of the SH3′ and SH3″ domains are labeled in pink and green, respectively. Interactions between the Itch PRR (dark yellow) and β-PIX SH3′ (C) or SH3″ (D) were generated by Ligplot+ as in B.