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(A) Animal from Grp P: bone marrow with positive staining, showing focal cytoplasmic and membrane reaction in mononuclear cells (arrow). (B) Animal from GrpM Lo: cartilage-bone transitional zone with a few Cox-2 positive fibroblasts, fibrocytes, and mononuclear cells (arrows). (C) Animal from GrpM Hi: hypercellular bone marrow, with rare Cox-2-positive cells (arrows).
