Figure 5.

Number of TM-helices in membrane proteins identified in the different cellular compartments as they compare to predicted domains in the genome. The different profiles were color-coded as shown above. The percentage of occurrence of membrane proteins domains with a given number of TM-helices were expressed as a percentage of the respective number of proteins found in each category. The relative number of TM proteins identified in the proteome corresponds with that of Mtb H37Rv genome, which possesses a large number of proteins with a smaller number of TM-helices, i.e., <7, and the number of proteins with >7 TM-helices decreases drastically. Also, proteins with TM-helices >10 predominate in the proteomics profile, which has the highest number of TM proteins in the membrane compartment, as expected, followed by cytosolic membrane proteins and then TM proteins found in the cell wall. SP, secreted proteins.