Table 2.
Pharmacokinetic parameters following single- and multiple-dose exposures of olopatadine 0.77% (pharmacokinetics population)
| Pharmacokinetic parameters | Single dose (Day 1) (n=24) | Multiple dose (Day 7) (n=22) |
|---|---|---|
| Cmax, ng/mL* (range) | 1.65 (0.62–4.12) | 1.45 (0.61–4.50) |
| Tmax, h** (range) | 2.00 (0.25–4.02) | 2.00 (0.25–8.00) |
| AUC0–12, ng⋅h/mL* (range) | 9.04 (4.05–18.40) | 8.78 (3.72–21.20) |
| t1/2, h# (range) | 2.90 (2.05–5.78) | 3.40 (2.13–7.77) |
Notes:
*
Cmax and AUC0–12 expressed as geometric means,
**
Tmax expressed as median,
#
t1/2 expressed as arithmetic mean. AUC0–12, area under the plasma concentration–time curve from 0 to 12 hours; Cmax, peak plasma concentration; Tmax, time to reach maximum plasma concentration; t1/2, elimination half-life.