Fig. 1.

The cortical signature of the Down syndrome brain without amyloid pathology: regional variations in cortical thickness across the hemispheres in the PIB-negative group (n = 27) in comparison to control group (n = 30). The color scale on the right represents the significance of the thickness difference as −log 10 (p-value) with red-yellow indicating thinner cortex and blue-light blue indicating thicker cortex in the PIB-negative group relative to controls. The results are false discovery rate corrected at p < 0.05.