Table 1.
Participant demographics
| Measure | Controls | PIB-negative | PIB-positive | PIB-positive excl. 3 non-CAMCOG participants |
|---|---|---|---|---|
| n, f/m | 30, 14/16 | 27, 13/14 | 19, 8/11 | 16, 6/10 |
| Age, range (y) | 46.2 ± 9.7, 30–64 | 37.1 ± 6, 28–48 | 49.7 ± 6.5, 39–65 | 48.1 ± 5.1, 39–56 |
| Global cortical thickness (mm) | 2.57 ± 0.09 | 2.68 ± 0.10 | 2.55 ± 0.12 | 2.56 ± 0.12 |
| TIV (cm3) | 1421.71 ± 140.58 | 1178.71 ± 103.13 | 1203.40 ± 124.10 | 1203.03 ± 115.00 |
| TIV-corrected TBVa (cm3) | 1151.26 ± 59.52 | 1148.86 ± 29.87 | 1067.08 ± 72.05 | 1070.26 ± 73.94 |
| Stable cogn./cogn. decline/dement. | N/A | 24/1/2 | 7/5/7 | 7/5/4 |
| CAMCOG score (max 109), range | N/A | 76, 38–102 | - | 74, 17–95 |
| ApoEb | ||||
| ε2/ε3 | N/A | 4 | 3 | 2 |
| ε3/ε3 | N/A | 15 | 6 | 6 |
| ε3/ε4 | N/A | 4 | 6 | 6 |
| ε2/ε4 | N/A | 1 | 1 | 1 |
Data is shown as mean ± standard deviation and range, if applicable.
Key: ApoE, apolipoprotein E allele; Cogn. decline, cognitive decline; Dement., dementia; f/m, females/males ratio; N/A, not applicable; Stable cogn., stable cognition; TBV, total brain volume; TIV, total intracranial volume.
b
Three individuals in the PIB-negative group and 3 in the PIB-positive group did not undergo ApoE genotyping.