Table S3.

Comparison of false-negative probabilities for LD and HIV testing based on clinical samples

Lyme disease stage	LD testing				HIV disease testing				False-negative ratio two-tier LD and two-stage HIV
	Test dependence 0.63				Test dependence 0.950
	Test sensitivity		Probability of a false-negative result		Test sensitivity		Probability of a false-negative result
	First tier	Second tier test	First tier test	Two-tier test	First stage	Second stage	Single-stage HIV test	Two-stage HIV test
Acute	20.4%	21.2%	79.6%	85.6%	98.6%	98.6%	1.40%	1.33%	64
Intermediate	30.4%	31.5%	69.6%	77.3%	98.9%	98.9%	1.10%	1.05%	74
Convalescent	37.2%	38.6%	62.8%	71.3%	99.4%	99.4%	0.60%	0.57%	125
Intermediate	45.5%	47.3%	54.5%	63.3%	99.7%	99.7%	0.30%	0.29%	222
Neuro/arthritis	53.1%	55.2%	46.9%	55.7%	99.9%	99.9%	0.100%	0.095%	586

Abbreviation: LD, Lyme disease; Neuro, neurological.