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. 2017 Apr 14;12(4):e0174443. doi: 10.1371/journal.pone.0174443

Table 4. Parameters associated with NO-releasing catheter–change from baseline within groups.

CT-Group NO-Group
Parameters N Mean±SEM % Change From Baseline P value N Mean±SEM % Change From Baseline P value
Blood Pressure (mmHg)
Baseline 6 101.90±7.79 6 95.26±1.39
1st day of Catheterization 6 96.47±6.20 -5.35 0.598 6 90.68±4.05 -4.80 0.349
Hospital Discharge 6 104.40±2.86 2.40 0.709 6 99.70±3.55 4.66 0.265
Catheter Removal 6 106.8±5.45 4.74 0.364 6 102.40±5.49 7.44 0.317
Follow-Up 6 106±3.801 4.04 0.514 6 98.08±3.595 2.97 0.564
Temperature (°C)
Baseline 6 36.75±0.11 6 36.68±0.06
1st day of Catheterization 6 36.86±0.09 0.29 0.405 6 36.81±0.16 0.35 0.46
Hospital Discharge 6 36.87±0.10 0.33 0.296 6 36.99±0.09 0.35 0.061
Catheter Removal 6 36.87±0.14 0.32 0.598 6 36.75±0.06 0.19 0.394
Follow-Up 6 36.88±0.130 0.36 0.299 6 36.77±0.080 0.23 0.434
PT (Sec)
Baseline 6 11.33±0.307 6 10.63±0.219
1st day of Catheterization 5 12.22±0.404 9.18 0.019 6 11.98±0.289 12.70 < 0.001
Hospital Discharge 6 11.98±0.547 5.74 0.160 6 11.40±0.330 7.15 0.005
Catheter Removal 4 12.38±0.914 6.80 0.292 6 11.18±0.236 5.17 0.005
Follow-Up 5 11.62±0.723 3.88 0.402 6 11.08±0.199 4.23 0.048
aPTT (Sec)
Baseline 6 32.65±0.896 5 32.24±1.627
1st day of Catheterization 5 28.42±2.321 -15.19 0.083 6 30.42±1.021 -6.33 0.035
Hospital Discharge 6 28.98±2.114 -11.21 0.150 6 32.28±1.031 -0.06 0.988
Catheter Removal 4 30.70±0.930 -5.73 0.048 6 34.15±1.411 5.65 0.088
Follow-Up 5 31.30±1.123 -2.14 0.441 6 33.63±1.476 4.96 0.013
INR
Baseline 6 0.92±0.022 6 0.88±0.011
1st day of Catheterization 5 0.99±0.032 7.61 0.055 6 0.99±0.020 12.50 < 0.001
Hospital Discharge 6 0.97±0.044 4.35 0.233 6 0.94±0.024 6.82 0.008
Catheter Removal 4 1.00±0.074 6.52 0.309 6 0.92±0.025 4.55 0.101
Follow-Up 5 0.94±0.059 2.17 0.603 6 0.89±0.016 2.27 0.233
Hemoglobin (g/dl)
Baseline 6 14.33±0.539 6 14.83±0.229
1st day of Catheterization 6 11.95±0.532 -16.61 < 0.001 6 13.23±0.161 -10.79 0.002
Hospital Discharge 6 12.72±0.711 -11.30 0.035 6 13.37±0.437 -9.91 0.016
Catheter Removal 6 13.17±0.766 -8.14 0.038 6 14.47±0.531 -2.49 0.517
Follow-Up 6 13.28±0.789 -7.33 0.075 6 14.43±0.438 -2.70 0.347
WBC (103/μl)
Baseline 6 6.51±0.497 6 9.307±1.283
1st day of Catheterization 6 8.34±1.003 28.11 0.042 6 7.74± 1.159 21.06 0.096
Hospital Discharge 6 8.62±0.796 32.41 0.093 6 7.438±1.038 7.95 0.416
Catheter Removal 6 8.09±0.530 24.27 0.125 6 9.89±1.164 21.06 0.091
Follow-Up 6 6.75±0.755 3.69 0.843 6 9.41±1.099 5.37 0.548
Neutrophils (103/μl)
Baseline 6 4.00±0.500 6 4.08± 0.368
1st day of Catheterization 6 6.50±0.800 62.50 0.015 6 6.90±1.248 69.12 0.041
Hospital Discharge 6 6.45±0.712 61.25 0.074 6 5.57±0.382 35.05 0.053
Catheter Removal 6 5.68±0.711 42.00 0.127 6 6.52±0.624 59.56 0.025
Follow-Up 6 4.63±0.847 15.75 0.599 6 5.02±0.240 22.79 0.084
Platelets (103/μl)
Baseline 6 297.5±81.7 6 213.2±12.21
1st day of Catheterization 6 273.0±105.0 -8.24 0.416 6 176.3±9.982 -17.27 0.005
Hospital Discharge 6 273.5±90.3 -8.07 0.179 6 193.50±13.4 -9.23 0.067
Catheter Removal 6 352.7±74.40 18.54 0.001 6 321.3±20.48 50.75 0.001
Follow-Up 6 305.3±86.50 2.63 0.679 6 224.7±24.12 5.39 0.619
CRP (mg/dl)
Baseline 5 0.31±0.100 5 0.25±0.120
1st day of Catheterization 5 2.75±0.951 867.74 0.084 6 3.57±0.551 1236.00 0.005
Hospital Discharge 6 7.86±3.797 2841.94 0.114 6 6.96±1.003 2684.00 0.005
Catheter Removal 6 4.82±3.838 1748.39 0.304 6 0.87±0.251 292.00 0.047
Follow-Up 6 4.65±3.865 1693.55 0.321 6 0.42±0.154 88.00 0.205

Changes in parameters values from baseline levels during the study within both study groups were evaluated at the 1st day of catheterization, at hospital discharge, at catheter removal day and at follow-up visit. Paired T-test was applied for analyzing changes from baseline levels. p > 0.05, non-statistically significant change from baseline. p < 0.05, statistically significant change from baseline.