Table 2. Prediction of the effects of HNF1A missense mutations on protein stability.
| Mutation | Mupro (SVM) | I-Mutant 2.0 (kcal/mol) | DUET (kcal/mol) |
|---|---|---|---|
| N127Y | 0.77534 | -0.04 | 0.01 |
| R131Q | -1 | -1.15 | -0.732 |
| R131W | -0.344 | -0.42 | -0.991 |
| S142F | 0.741 | -0.55 | 0.307 |
| R159W | -0.061 | -0.54 | -0.319 |
| R200W | 0.334 | -0.77 | 0.02 |
| R203C | -0.4437 | -0.35 | -0.402 |
| R263C | -0.304 | -1.55 | 2.042 |
The numerical value denotes the 'delta delta G’ (DDG). A DDG value<0 indicates a decrease in stability, and DDG value >0 indicates an increase in stability.