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. 2005 Jan 3;115(1):138–145. doi: 10.1172/JCI22232

Figure 5.

Figure 5

Effects of a high-fat diet on β cell phenotype in βPKCλ–/– mice. (A) Blood glucose and plasma insulin concentrations in the fed state of control and βPKCλ–/– mice on a high-fat diet. Data are means ± SE of values from 12 animals of each genotype. (B) Intraperitoneal glucose tolerance tests in control (open circles) and βPKCλ–/– (filled circles) mice after 15 weeks on the high-fat diet. Data are means ± SE of values from 6 animals of each genotype. *P < 0.05 (ANOVA) versus the corresponding value for control mice. (C) Immunostaining of pancreatic sections from control and βPKCλ–/– mice after 15 weeks on the high-fat diet with antibodies against insulin (red) and glucagon (green). Scale bars: 100 μm. (D) Quantitation of β cell area as a percentage of total pancreatic area in control and βPKCλ–/– mice after 15 weeks on the high-fat diet. Data are means ± SE of values from 3 mice of each genotype.