Table 4. The positively selected sites from selection pressure analysis of the NA gene of Thai seasonal influenza isolates.
Types/Subtypes | Global ω | No. of positively selected sites (codon position) | ||
---|---|---|---|---|
by SLAC | SLAC | FEL | MEME | |
A(H1N1)seasonal | 0.26 | 3 (77, 222, 452) | 5 (77, 222, 249, 344, 452) | 7 (7, 77, 222, 249, 266, 344, 452) |
A(H1N1)pdm09 | 0.31 | 1 (463) | 7 (13, 34, 48, 188, 270, 451, 463) | 6 (13, 34, 48, 188, 366, 463) |
A(H3N2) | 0.24 | 4 (93, 215, 401, 468) | 9 (4, 43, 93, 141, 150, 215, 401, 464, 468) | 12 (4, 43, 93, 141, 181, 215, 267, 271, 401, 402, 464, 468) |
B | 0.30 | 3 (73, 395, 404) | 9 (68, 73, 106, 220, 248, 358, 395, 404, 465) | 13 (15, 27, 41, 51, 73, 106, 107, 219, 220, 358, 395, 404, 465) |
Global ω denotes the ratio of nonsynonymous substitutions (dN) to synonymous substitutions (dS).
SLAC, single-likelihood ancestor counting; FEL, fixed effects likelihood; MEME, mixed effects model of evolution.