Table 2. Multivariable Cox proportional hazards model for survival outcomes.
| OST | RFT | DST | ||||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| No. of Patients | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | ||
| Age | 10 years unit | 683 | 1.30 (1.12, 1.51) | 0.0005 | 1.16 (1.00, 1.35) | 0.05 | 1.12 (0.93, 1.36) | 0.24 |
| Gender | Male | 500 | (ref) | (ref) | (ref) | |||
| Female | 183 | 1.07 (0.74, 1.54) | 0.73 | 0.95 (0.65, 1.39) | 0.79 | 1.08 (0.68, 1.73) | 0.74 | |
| Married | Married | 434 | 0.77 (0.55, 1.09) | 0.14 | 0.78 (0.55, 1.10) | 0.15 | 0.90 (0.58, 1.39) | 0.63 |
| Not Married | 249 | (ref) | (ref) | (ref) | ||||
| Prior Cancer | 108 | 0.83 (0.53, 1.30) | 0.41 | 0.73 (0.46, 1.16) | 0.18 | 0.67 (0.37, 1.23) | 0.20 | |
| Prior HNSCC | 31 | 2.31 (1.25, 4.26) | 0.008 | 2.73 (1.54, 4.84) | 0.0006 | 2.77 (1.31, 5.87) | 0.008 | |
| Ca Stage | I/Cis | 107 | (ref) | (ref) | (ref) | |||
| II | 78 | 3.24 (1.31, 8.02) | 0.01 | 1.40 (0.55, 3.54) | 0.48 | 2.37 (0.56, 9.97) | 0.24 | |
| III | 97 | 5.02 (2.14, 11.80) | 0.0002 | 3.34 (1.53, 7.31) | 0.003 | 6.58 (1.87, 23.19) | 0.003 | |
| IV | 401 | 7.20 (3.29, 15.73) | <0.0001 | 5.03 (2.50, 10.11) | <0.0001 | 10.54 (3.26, 34.05) | <0.0001 | |
| Disease Site | Oral Cavity | 269 | (ref) | (ref) | (ref) | |||
| Hypopharynx | 23 | 0.76 (0.35, 1.66) | 0.50 | 1.11 (0.53, 2.33) | 0.79 | 0.92 (0.37, 2.31) | 0.86 | |
| Larynx | 135 | 0.52 (0.33, 0.82) | 0.005 | 0.66 (0.42, 1.04) | 0.08 | 0.62 (0.35, 1.08) | 0.09 | |
| Oropharynx | 256 | 0.72 (0.47, 1.11) | 0.14 | 0.81 (0.52, 1.25) | 0.33 | 0.72 (0.41, 1.26) | 0.25 | |
| ACE comorbidity | none | 182 | (ref) | (ref) | (ref) | |||
| mild | 320 | 1.63 (1.00, 2.67) | 0.05 | 1.27 (0.81, 2.01) | 0.30 | 1.35 (0.75, 2.41) | 0.31 | |
| moderate | 125 | 2.66 (1.58, 4.47) | 0.003 | 1.69 (1.00, 2.87) | 0.05 | 1.81 (0.92, 3.54) | 0.08 | |
| severe | 56 | 2.69 (1.38, 5.25) | 0.004 | 1.95 (1.01, 3.78) | 0.05 | 2.72 (1.21, 6.12) | 0.02 | |
| BMI | 1 unit increase | 683 | 0.96 (0.93, 0.99) | 0.01 | 0.98 (0.95, 1.00) | 0.09 | 0.97 (0.93, 1.00) | 0.06 |
| HPV status | HPV- | 221 | (ref) | (ref) | (ref) | |||
| HPV+ | 140 | 0.41 (0.22, 0.73) | 0.003 | 0.48 (0.27, 0.84) | 0.01 | 0.37 (0.17, 0.77) | 0.008 | |
| Unknown | 322 | 0.83 (0.58, 1.20) | 0.32 | 0.79 (0.55, 1.15) | 0.22 | 0.73 (0.46, 1.17) | 0.20 | |
| Alcohol Use | never | 66 | (ref) | (ref) | (ref) | |||
| current | 448 | 1.21 (0.68, 2.15) | 0.51 | 0.86 (0.50, 1.49) | 0.60 | 0.96 (0.48, 1.92) | 0.90 | |
| former | 169 | 1.16 (0.64, 2.12) | 0.62 | 0.90 (0.51, 1.61) | 0.72 | 0.99 (0.47, 2.07) | 0.98 | |
| Cigarette Use | never | 183 | 0.76 (0.45, 1.28) | 0.30 | 0.95 (0.59, 1.53) | 0.83 | 0.81 (0.42, 1.54) | 0.81 |
| Pack Years | 10 unit increase | 683 | 1.05 (0.99, 1.11) | 0.13 | 1.05 (0.98, 1.12) | 0.14 | 1.04 (0.96, 1.13) | 0.33 |
Abbreviations: No.=Number, OST=Overall Survival Time, RFT=Recurrence-Free Time, DST=Disease Specific Survival Time, HR=Hazard Ratio, CI=Confidence Interval, HNSCC=Head and Neck Squamous Cell Cancer, Cis=insitu, ACE=Adult Comorbidity Evaluation-27 summary score, BMI=Body Mass Index, HPV= Human papillomavirus