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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Head Neck. 2016 Jul 19;38(12):1810–1820. doi: 10.1002/hed.24515

Table 2. Multivariable Cox proportional hazards model for survival outcomes.

OST RFT DST

No. of Patients HR (95% CI) p-value HR (95% CI) p-value HR (95% CI) p-value
Age 10 years unit 683 1.30 (1.12, 1.51) 0.0005 1.16 (1.00, 1.35) 0.05 1.12 (0.93, 1.36) 0.24
Gender Male 500 (ref) (ref) (ref)
Female 183 1.07 (0.74, 1.54) 0.73 0.95 (0.65, 1.39) 0.79 1.08 (0.68, 1.73) 0.74
Married Married 434 0.77 (0.55, 1.09) 0.14 0.78 (0.55, 1.10) 0.15 0.90 (0.58, 1.39) 0.63
Not Married 249 (ref) (ref) (ref)
Prior Cancer 108 0.83 (0.53, 1.30) 0.41 0.73 (0.46, 1.16) 0.18 0.67 (0.37, 1.23) 0.20
Prior HNSCC 31 2.31 (1.25, 4.26) 0.008 2.73 (1.54, 4.84) 0.0006 2.77 (1.31, 5.87) 0.008
Ca Stage I/Cis 107 (ref) (ref) (ref)
II 78 3.24 (1.31, 8.02) 0.01 1.40 (0.55, 3.54) 0.48 2.37 (0.56, 9.97) 0.24
III 97 5.02 (2.14, 11.80) 0.0002 3.34 (1.53, 7.31) 0.003 6.58 (1.87, 23.19) 0.003
IV 401 7.20 (3.29, 15.73) <0.0001 5.03 (2.50, 10.11) <0.0001 10.54 (3.26, 34.05) <0.0001
Disease Site Oral Cavity 269 (ref) (ref) (ref)
Hypopharynx 23 0.76 (0.35, 1.66) 0.50 1.11 (0.53, 2.33) 0.79 0.92 (0.37, 2.31) 0.86
Larynx 135 0.52 (0.33, 0.82) 0.005 0.66 (0.42, 1.04) 0.08 0.62 (0.35, 1.08) 0.09
Oropharynx 256 0.72 (0.47, 1.11) 0.14 0.81 (0.52, 1.25) 0.33 0.72 (0.41, 1.26) 0.25
ACE comorbidity none 182 (ref) (ref) (ref)
mild 320 1.63 (1.00, 2.67) 0.05 1.27 (0.81, 2.01) 0.30 1.35 (0.75, 2.41) 0.31
moderate 125 2.66 (1.58, 4.47) 0.003 1.69 (1.00, 2.87) 0.05 1.81 (0.92, 3.54) 0.08
severe 56 2.69 (1.38, 5.25) 0.004 1.95 (1.01, 3.78) 0.05 2.72 (1.21, 6.12) 0.02
BMI 1 unit increase 683 0.96 (0.93, 0.99) 0.01 0.98 (0.95, 1.00) 0.09 0.97 (0.93, 1.00) 0.06
HPV status HPV- 221 (ref) (ref) (ref)
HPV+ 140 0.41 (0.22, 0.73) 0.003 0.48 (0.27, 0.84) 0.01 0.37 (0.17, 0.77) 0.008
Unknown 322 0.83 (0.58, 1.20) 0.32 0.79 (0.55, 1.15) 0.22 0.73 (0.46, 1.17) 0.20
Alcohol Use never 66 (ref) (ref) (ref)
current 448 1.21 (0.68, 2.15) 0.51 0.86 (0.50, 1.49) 0.60 0.96 (0.48, 1.92) 0.90
former 169 1.16 (0.64, 2.12) 0.62 0.90 (0.51, 1.61) 0.72 0.99 (0.47, 2.07) 0.98
Cigarette Use never 183 0.76 (0.45, 1.28) 0.30 0.95 (0.59, 1.53) 0.83 0.81 (0.42, 1.54) 0.81
Pack Years 10 unit increase 683 1.05 (0.99, 1.11) 0.13 1.05 (0.98, 1.12) 0.14 1.04 (0.96, 1.13) 0.33

Abbreviations: No.=Number, OST=Overall Survival Time, RFT=Recurrence-Free Time, DST=Disease Specific Survival Time, HR=Hazard Ratio, CI=Confidence Interval, HNSCC=Head and Neck Squamous Cell Cancer, Cis=insitu, ACE=Adult Comorbidity Evaluation-27 summary score, BMI=Body Mass Index, HPV= Human papillomavirus