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. 2005 Jan 3;115(1):35–43. doi: 10.1172/JCI22656

Figure 4.

Figure 4

Increased mucus production in the lungs of ADA/A1AR double-knockout mice. Lung sections from postnatal day 14 mice were stained with PAS for the detection of mucus (arrows). Images show (A) lung from an ADA+A1AR+/+ mouse, (B) lung from an ADA+A1AR–/– mouse, (C) lung from an ADA–/–A1AR+/+ mouse, and (D) lung from an ADA–/–A1AR–/– mouse. Scale bar: 100 μm. (E) A mean mucus index ± SEM was determined as described in Methods; n = 5 for each group. (F) Levels of mucus-associated genes were determined in whole-lung extracts from postnatal day 14 mice, using quantitative RT-PCR. Data are presented as mean pg of transcripts/μg RNA ± SEM; n = 8 for each group. *P – 0.05 compared to ADA+ mice; **P – 0.05 compared to ADA–/–A1AR+/+ mice.