Table 4.
Summary of biomarkers by SSNS/SRNS.
| VARIABLE | Mean (95% CI) |
Fold (SRNS/SSNS) | P | |
|---|---|---|---|---|
| SRNS | SSNS | |||
| All (N = 50) | ||||
| n = 20 | n = 30 | |||
| VDBP | 2519.41 (669.59–9479.56) | 66.25 (22.46–195.47) | 38.0 | <.001 |
| NGAL | 30.77 (15.01–63.08) | 5.57 (3.10–10.00) | 5.5 | .001 |
| Fetuin-A | 36 723.78 (13 878.94–97 171.38) | 3433.82 (1551.44–7600.15) | 10.7 | <.001 |
| Prealbumin | 20 685.39 (7391.11–57 891.95) | 1649.83 (712.04–3822.76) | 12.5 | <.001 |
| AGP2 | 141.30 (54.38–367.14) | 35.79 (16.41–78.04) | 3.9 | .030 |
| AGP1 | 90.97 (13.43–616.16) | 82.89 (17.38–395.22) | 1.1 | .940 |
| A2MCG | 119.93 (40.33–356.62) | 35.79 (14.70–87.13) | 3.4 | .090 |
| A1BG | 310.97 (146.86–658.43) | 192.57 (104.37–355.31) | 1.6 | .325 |
| TBG | 1136.19 (320.34–4029.90) | 730.91 (259.97–2054.98) | 1.6 | .590 |
| Hemopexin | 4701.67 (1993.48–11 089.00) | 2049.40 (1017.11–4129.39) | 2.3 | .138 |
| Relapse (N = 31) | ||||
| n = 17 | n = 14 | |||
| VDBP | 3708.40 (1010.16–13 613.90) | 353.58 (84.36–1482.06) | 10.5 | .018 |
| NGAL | 33.48 (15.22–73.64) | 7.16 (3.00–17.06) | 4.7 | .011 |
| Fetuin-A | 55 745.38 (23 435.74–132 598.64) | 15 607.72 (6006.81–40 554.13) | 3.6 | .053 |
| Prealbumin | 33 079.70 (12 129.94–90 212.00) | 5000.48 (1655.35–15 105.43) | 6.6 | .014 |
| AGP2 | 171.01 (81.37–359.43) | 266.72 (117.65–604.69) | 0.6 | .422 |
| AGP1 | 141.97 (22.88–881.03) | 1340.72 (179.35–10 022.32) | 0.1 | .103 |
| A2MCG | 137.11 (44.26–424.79) | 110.19 (31.70–383.10) | 1.2 | .795 |
| A1BG | 318.05 (139.00–727.74) | 241.52 (97.01–601.29) | 1.3 | .655 |
| TBG | 1639.78 (419.97–6402.53) | 1237.83 (275.92–5553.08) | 1.3 | .781 |
| Hemopexin | 4019.45 (1583.99–10 199.55) | 3126.86 (1120.64–8724.72) | 1.3 | .717 |
Abbreviations: AGPI, alpha-1 acid glycoprotein 1; AGP2, alpha-1 acid glycoprotein 2; CI, confidence interval; NGAL, neutrophil gelatinase–associated lipocalin; SRNS, steroid-resistant nephrotic syndrome; SSNS, steroid-sensitive nephrotic syndrome; VDBP, vitamin D–binding protein. Italicized font represents biomarker included in MLM-5.