Table 7.
Algorithms of computing risk scores of SRNS.
| Step | MLM-10 (any patient) | MLM-5 (any patient) | MLM-10 (relapsed patient only) | MLM-5 (relapsed patient only) |
|---|---|---|---|---|
| 1 | Converting all biomarkers into log2 values | Converting all biomarkers into log2 values | Converting all biomarkers into log2 values | Converting all biomarkers into log2 values |
| 2 | Each biomarker is adjusted by a multiplier in the following: 0.27 × VDBP −0.004 × Prealbumin 0.51 × NGAL 0.37 × fetuin-A 0.50 × AGP2 −0.49 × AGP1 0.22 × A2MCG 0.20 × Hemopexin −0.09 × TBG 0.11 × A1BG |
Each biomarker is adjusted by a multiplier in the following: 0.23 × VDBP −0.03 × Prealbumin 0.32 × NGAL 0.01 × fetuin-A 0.03 × AGP2 |
Each biomarker is adjusted by a multiplier in the following: 0.23 × VDBP 0.07 × prealbumin 0.82 × NGAL 0.41 × fetuin-A 0.42 × AGP2 −0.60 × AGP1 0.24 × A2MCG 0.36 × Hemopexin −0.15 × TBG 0.24 × A1BG |
Each biomarker is adjusted by a multiplier in the following: 0.14 × VDBP 0.16 × prealbumin 0.26 × NGAL −0.05 × fetuin-A −0.47 × AGP2 |
| 3 | Sum of the adjusted biomarkers | Sum of the adjusted biomarkers | Sum of the adjusted biomarkers | Sum of the adjusted biomarkers |
| 4 | Calculate a raw score by subtracting 13.65 from the sum in step 3 | Calculate a raw score by subtracting 3.58 from the sum in step 3 | Calculate a raw score by subtracting 17.27 from the sum in step 3 | Calculate a raw score by subtracting 0.03 from the sum in step 3 |
| 5 | Calculate the risk score by taking 2 to the power of the raw score in step 4 | Calculate the risk score by taking 2 to the power of the raw score in step 4 | Calculate the risk score by taking 2 to the power of the raw score in step 4 | Calculate the risk score by taking 2 to the power of the raw score in step 4 |
| 6 | Compare the risk score with the cutoff point 0.49: SRNS positive if the score > cutoff SRNS negative if the score ⩽ cutoff |
Compare the risk score with the cutoff point 0.50: SRNS positive if the score > cutoff SRNS negative if the score ⩽ cutoff |
Compare the risk score with the cutoff point 0.60: SRNS positive if the score > cutoff SRNS negative if the score ⩽ cutoff |
Compare the risk score with the cutoff point 0.60: SRNS positive if the score > cutoff SRNS negative if the score ⩽ cutoff |
Abbreviations: AGPI, alpha-1 acid glycoprotein 1; AGP2, alpha-1 acid glycoprotein 2; NGAL, neutrophil gelatinase–associated lipocalin; SRNS, steroid-resistant nephrotic syndrome; TBG, thyroxine-binding globulin; VDBP, vitamin D–binding protein.