Table 4.

Differential regulation of oxidative stress–related genes exhibiting statistically significant differences in autistic patients compared with healthy controls.

Gene symbol	Gene description	Unigene	Refseq	Differential expression mild and moderate/C	P value
CCL5	Chemokine (C-C motif) ligand 5	Hs.514821	NM_002985	−1.7112	.02
GCLC	Glutamate-cysteine ligase, catalytic subunit	Hs.654465	NM_001498	−1.7994	.03
DHCR24	24-dehydrocholesterol reductase	Hs.498727	NM_014762	2.4566	.04
GPX7	Glutathione peroxidase 7	Hs.43728	NM_015696	1.4515	.05
Gene symbol	Gene description	Unigene	Refseq	Differential expression severe/C	P value
GCLM	Glutamate-cysteine ligase, modifier subunit	Hs.315562	NM_002061	−1.651	.01
GPX7	Glutathione peroxidase 7	Hs.43728	NM_015696	1.5511	.01
SOD2	Superoxide dismutase 2, mitochondrial	Hs.487046	NM_000636	−2.4852	.01
TXN	Thioredoxin	Hs.435136	NM_003329	−2.1735	.03
NCF2	Neutrophil cytosolic factor 2	Hs.587558	NM_000433	−1.8704	.04
PRNP	Prion protein	Hs.610285	NM_183079	−1.9816	.04
PTGS2	Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	Hs.196384	NM_000963	−4.2673	.05
FTH1	Ferritin, heavy polypeptide 1	Hs.712676	NM_002032	−1.454	.05

Differential expression of the most regulated oxidative stress–related genes (fold regulation ⩾ 1.5 [upregulation/downregulation] with P ≤ .05) in mild/moderate (Table 4) or severe (Table 4) autistic patients compared with healthy controls (C). A negative sign refers to downregulation in patients relative to the healthy ones. Genes are arranged in a descending order according to their significant P value.