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. Author manuscript; available in PMC: 2018 Apr 5.
Published in final edited form as: Neuron. 2017 Apr 5;94(1):58–64.e3. doi: 10.1016/j.neuron.2017.03.018

Figure 2. Effects of domain swapping on NMDAR deactivation kinetics.

Figure 2

(A) Deactivation kinetics of A/A receptors with one (A/Ab) or both ATDs (Ab/Ab) swapped to the GluN2B ATD. The red and blue dotted lines indicate deactivation time course for wildtype A/A and B/B receptors, respectively (same in B and C). (B) Deactivation of B/B receptors with single ATD (Ba/B) or both ATDs (Ba/Ba; green trace) swapped to the GluN2A ATD. (C) Deactivation of A/A receptors with a single GluN2A LBD+TMD swapped to the GluN2B LBD+TMD (Ba/A) and B/B receptors with a single GluN2B LBD+TMD swapped to the GluN2A LBD+TMD (Ab/B).