Figure 3.

Comparison of K_{P,AUC,Spinal cord} of digoxin when administered alone and in combination with elacridar and/or rifampicin. The numbers above each bar indicate the fold increase in K_{P,AUC,Spinal cord} compared with digoxin alone. For each group, 15 rats were used, of which 3 rats were used for each sampling time point. As the K_{P,AUC,Spinal cord} was calculated using the K_{P,Spinal cord} at each time point collected from different sets of rats, error bars were not included. D indicates digoxin; E, elacridar; R, rifampicin.