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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: J Allergy Clin Immunol. 2016 Apr 25;138(3):908–911.e9. doi: 10.1016/j.jaci.2016.01.056

Fig. 1. Volcano plot showing the significance and magnitude of autosomal DNA methylation changes associated with cow's milk allergy (CMA).

Fig. 1

Mean differences in DNA methylation (cases-controls) are plotted on the x-axis and corresponding -log10(p-value)s are plotted on the y-axis. Each point represents a measured CpG site. Black and blue points represent CpG sites significantly hypomethylated and hypermethyated in CMA cases, respectively. Red points represent those significant CpG sites with DNA methylation difference >5% between cases and controls. The red dashed horizontal line represents the genome-wide significance threshold (p=1.15E-07).