Table 1.

Summary of integration events in HPV-positive cell lines.

Cell Line	Patient Information	HPV Site	Cellular Integration Site
			Locus	Gene	Region
UD-SCC-2	58-year-old male smoker with T1N3 SCC of the pyriform sinus, died by pulmonary metastases 1 year after diagnosis	E2	17q12	Intergenic
		E1	1p32.3	JAK1	Intron 14
UM-SCC-47	53-year-old male smoker with T3N1M0 lateral tongue SCC, died from disease within a year of diagnosis	E2	3q28	TP63	Intron 10
		E2	3q28	TP63	Exon 14
UM-SCC-104	56-year-old male smoker with recurrent floor of mouth T4N2bM0 SCC, died from disease within a year after treatment	E2	17q22	Intergenic
		E2	17p11.2	Intergenic
		E1	18q21.3	DCC	Intron 1
UPCI:SCC90	46-year-old male smoker with recurrent base of tongue T2N1M0 SCC, died from disease 4 years after diagnosis*	E1	9q31.1	Intergenic
		E1	12p13	ETV6	Intron 1
UPCI:SCC152	47-year-old male smoker (donor of UPCI:SCC90) with recurrent hypopharynx SCC, died from disease 4 years after diagnosis*	E2	9q22.33	Intergenic
		E1	9q31.1	Intergenic
		LCR	3q23	ATR	Intron 36
		E1	12p13	ETV6	Intron 1
UPCI:SCC154	52-year-old male smoker with base of tongue T4N2 SCC, alive 10 years after surgery	E1	21p11.1	Intergenic
		E2	2q33.2	TMEM237	Exon 14
		E2	7q36	PTPRN2	Intron 3
		E1	11q22–23	PGR	Intron 3
VU-SCC-147	57-year-old male smoker with floor of mouth T4N2 SCC, developed untreatable second primary after 6.5 years	E1	17q21	Intergenic
		L2	3p21	Intergenic
		E2	5p15.33	TERT	Promoter
UM-GCC-1	26-year old female, stage IB cervical carcinoma, alive without disease 30 years after diagnosis	L1	20p13	Intergenic
UM-SCC-105	51-year old male never smoker with T4N0M0 larynx carcinoma, alive without disease 5 years after treatment	L1	8q12.3/4p15.33	Intergenic
		L1	17q12	Intergenic

^*UPCI:SCC90 and UPCI:SCC152 are from the same patient