Table 2.
Blind prediction performance of the TB risk signature on the ACS test set by RNA-Seq and qRT-PCR, and on the GC6-74 cohorts from South Africa and The Gambia by qRT-PCR.
| Prediction accuracy (95% CI) | |||||||
|---|---|---|---|---|---|---|---|
| Cohort | Platform | Days before TB |
ROC AUC (95% CI) |
ROC p- value |
Sensitivity | Specificity | Threshold |
| ACS Test | |||||||
| All ACS Test |
RNA-Seq | 0·686 (0·523, 0·849) |
0·018 | 41·7% (22·3%, 64·5%) |
89·9% (82·6%, 94·0%) |
82% | |
| All ACS Test |
qRT-PCR | 0·693 (0·536, 0·850) |
0·0095 | 46·7% (27·8%, 66·6%) |
90·9% (83·8%, 94·7%) |
76% | |
| GC6-74 | |||||||
| All GC6- 74 |
qRT-PCR | 1–720 | 0·694 (0·625, 0·763) |
<0·0001 | 48·8% (39·9%, 57·7%) |
82·8% (78·7%, 86%) |
76% |
| South Africa |
qRT-PCR | 1–720 | 0·720 (0·633, 0·806) |
<0·0001 | 43·2% (31·7%, 55·5%) |
87·7% (82·7%, 91·2%) |
79% |
| The Gambia |
qRT-PCR | 1–720 | 0·665 (0·555, 0·775) |
0·001 | 50% (37·1%, 62·8%) |
81·9% (75·5%, 86·7%) |
78% |
| All GC6- 74 |
qRT-PCR | 1–360 | 0·718 (0·637, 0·800) |
<0·0001 | 53·7% (42·6%, 64·3%) |
82·8% (78·7%, 86%) |
76% |
| All GC6- 74 |
qRT-PCR | 361–720 | 0·648 (0·532, 0·764) |
0·0048 | 39·3% (25·8%, 54·8%) |
85·5% (81·7%, 88·5%) |
79% |