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. 2015 May 27;8(11):17593–17609. doi: 10.18632/oncotarget.4307

Figure 5. Pimozide inhibits the self-renewal and migration capacities of CD133-positive HCC cells.

Figure 5

A. Fluorescence-activated cell sorting isolation of CD133-positive cells and negative cells from MHCC-97L cells (a). The purity of fluorescence-activated cell sorting isolation was confirmed (b). B. Colony formation assay of CD133-positive and negative MHCC-97L cells treated with the indicated doses of pimozide. The images (a) and statistical results (b) are shown. C. Sphere formation assay of CD133-positive and negative MHCC-97L cells treated with pimozide. D. Transwell migration assay of CD133-positive MHCC-97L cells treated with 10 μM pimozide for 24h. Images are shown at a magnification of 100×, and the statistical results are shown. The data are summarized from 3 independent experiments, *p < 0.05, **p < 0.01, compared to the control.