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. 2017 Feb 16;8(11):17610–17627. doi: 10.18632/oncotarget.15381

Figure 3. Runx1 reverses TGFβ induced EMT.

Figure 3

A. Images of MCF10A cells treated with TGFβ show morphological changes toward an EMT-like state. Overexpressing Runx1 in TGFβ treated cells rescued cell morphology to an epithelial-like state. B. RT-qPCR of RNA from MCF10A cells show changes in gene expression by overexpressing Runx1 in TGFβ-treated cells, which activates E-cadherin and represses Vimentin expression. Student's t test * p value <0.05 for HA-Runx1 overexpression in MFC10A cells compared to EV control cells. Error bars represent the standard error of the mean (SEM) from three independent experiments.