Table 2. Gene Ontology (GO) categories (biological processes) enriched for both up and down-regulated genes in one-hit TSC1/2 cells.
| GOBPID | Term | a3 |
|---|---|---|
| GO:0010986 | positive regulation of lipoprotein particle clearance | LIPG |
| GO:0060074 | synapse maturation | ERBB4 |
| GO:0051301 | cell division | CAT,CCNA2,CCNG2,CDK1 |
| GO:0007095 | mitotic cell cycle G2/M transition DNA damage checkpoint | CCNA2 |
| GO:0043551 | regulation of phosphoinositide 3-kinase activity | VAV3 |
| GO:0050847 | progesterone receptor signaling pathway | UBR5 |
| GO:0030518 | steroid hormone receptor signaling pathway | UBR5,MED14 |
| GO:0051973 | positive regulation of telomerase activity | PARM1 |
| GO:0042542 | response to hydrogen peroxide | ERBB4,CAT |
| GO:0009101 | glycoprotein biosynthetic process | MGAT4A,ST8SIA4,CHST9 |
| Downregulated biological processes | ||
| GO:0007568 | aging | CDKN2A,CRYAB,SERPINE1 |
| GO:0001300 | chronological cell aging | SERPINE1 |
| GO:0002691 | regulation of cellular extravasation | ICAM1 |
| GO:0022614 | membrane to membrane docking | ICAM1,VCAM1 |
| GO:0042110 | T cell activation | CDKN2A,ICAM1,VCAM1 |
| GO:0033079 | immature T cell proliferation | CDKN2A |
| GO:0032836 | glomerular basement membrane development | WT1 |
| GO:0010389 | regulation of G2/M transition of mitotic cell cycle | CDKN2A |
| GO:0031641 | regulation of myelination | CDH2 |
| GO:0000302 | response to reactive oxygen species | CRYAB,SERPINE1 |
The enrichment analysis was done using GO-Stats package (Bioconductor). Categories were selected based on p-value cutoff < 0.01.