Skip to main content
. 2017 Feb 1;8(11):17995–18009. doi: 10.18632/oncotarget.14929

Figure 1. Targeting KRAS in combination with HDACs overcomes drug resistance in lung cancer cells.

Figure 1

A. Western blot analysis of mouse KRAS G12D lung epithelial cells and human A549 lung cancer cells treated with the indicated inhibitors at 0.1 μM for 24 hrs. B. Clonal KRAS G12D cell lines (n=17) were maintained in DME supplemented with different concentrations of FBS and treated with BGT inhibitors at 0.1 μM for 3 d. Fold change in cell numbers relative to input cells is shown. Error bars represent the standard deviation. P-values were <0.05 for each treatment group. C, D. Human KRAS mutant (n=8) (C) or KRAS/BRAF WT NSCLC cell lines (n=12) (D) were maintained in DME supplemented with different concentrations of FBS and treated with BGT inhibitors at 0.1 μM for 3 d. Fold change in cell numbers relative to input cells is shown. Error bars represent the standard deviation. P-values were <0.05 for each treatment group. E. A549 cells were treated for 3 d with BGT at 0.2 μM or with the indicated cisplatin-based drugs combination at 10 μM each. Fold change in cell numbers relative to input cells is shown. Error bars represent the standard deviation. *Statistically significant, p<0.05.