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. 2017 Feb 8;8(11):18154–18165. doi: 10.18632/oncotarget.15186

Figure 4. Differential sensitivity of HNSCC cells to cisplatin (CDDP) and carboplatin (CBP).

Figure 4

A. Using standard MTT assay, GI50 values were calculated for both HN30 and HN31. B. HNSCC (HN31) cells were exposed to CBP or CDDP in the presence or absence of NAC. Differential effects on survival were calculated using clonogenic survival assay. C. HNSCC cells were exposed to CBP or CDDP for 1hr prior to measurements of cellular lactate levels. HN30 cells demonstrated approximately 25-60% decrease in lactate levels across the range of tested CBP doses compared to approximately 10% decrease in their counterpart, HN31. * indicates p-value < 0.05 compared to corresponding control condition. All values normalized to corresponding control condition. Each experiment was carried out at least in triplicate, with values indicating means and error bars representing standard deviation.