Table 2. Allele frequencies in cases and controls and odds ratio estimates for HAPE risk.
SNP | Gene | Band | Base Change | MAF-case | MAF-control | p value for HWEtest | OR | 95%CI | p value | |
---|---|---|---|---|---|---|---|---|---|---|
rs17778257 | ADRB2 | 5q32 | A/T | 0.36 | 0.35 | 0.38 | 1.03 | 0.81 | 1.31 | 0.827 |
rs2400707 | ADRB2 | 5q32 | A/G | 0.29 | 0.34 | 0.80 | 0.81 | 0.63 | 1.04 | 0.093 |
rs17108803 | ADRB2 | 5q32 | G/T | 0.05 | 0.05 | 0.48 | 0.98 | 0.56 | 1.71 | 0.940 |
rs12654778 | ADRB2 | 5q32 | A/G | 0.36 | 0.34 | 0.31 | 1.06 | 0.83 | 1.35 | 0.642 |
rs11168070 | ADRB2 | 5q32 | C/G | 0.09 | 0.09 | 0.73 | 0.95 | 0.63 | 1.43 | 0.815 |
rs1042718 | ADRB2 | 5q32 | A/C | 0.36 | 0.30 | 0.68 | 1.29 | 1.01 | 1.67 | 0.045* |
rs3842727 | TH | 11p15.5 | G/T | 0.04 | 0.04 | 1.00 | 0.95 | 0.52 | 1.73 | 0.860 |
rs2070762 | TH | 11p15.5 | A/G | 0.39 | 0.36 | 0.14 | 1.13 | 0.89 | 1.44 | 0.311 |
rs10770140 | TH | 11p15.5 | C/T | 0.09 | 0.09 | 1.00 | 1.10 | 0.74 | 1.66 | 0.632 |
rs10770141 | TH | 11p15.5 | A/G | 0.08 | 0.08 | 0.24 | 1.00 | 0.66 | 1.53 | 0.992 |
rs10840491 | TH | 11p15.5 | A/G | 0.10 | 0.09 | 1.00 | 1.11 | 0.74 | 1.66 | 0.611 |
rs7119275 | TH | 11p15.5 | C/T | 0.09 | 0.09 | 0.15 | 1.06 | 0.70 | 1.59 | 0.795 |
rs749174 | GSTP1 | 11q13.2 | A/G | 0.14 | 0.18 | 0.85 | 0.72 | 0.52 | 0.99 | 0.042* |
rs4963516 | GNB3 | 12p13.31 | G/T | 0.29 | 0.37 | 0.27 | 0.70 | 0.55 | 0.90 | 0.006* |
rs5446 | GNB3 | 12p13.31 | C/T | 0.20 | 0.20 | 0.15 | 1.02 | 0.76 | 1.36 | 0.914 |
MAF= minor allele frequency; HWE= Hardy–Weinberg Equilibrium; OR =odds ratio; 95 % CI = 95 % confidence interval;
*p < 0.05 indicates statistical significance