Table 3. Single-SNP analysis (rs1042718, rs749174 and rs4963516) under different genetic models (adjusted by age and gender).
| SNP | Model | Genotype | control | case | OR (95% CI) | p |
|---|---|---|---|---|---|---|
| rs1042718 | Co-dominant | C/C | 144 (49%) | 110 (43.5%) | 1 | 0.140 |
| C/A | 121 (41.2%) | 103 (40.7%) | 1.12 (0.77-1.62) | |||
| A/A | 29 (9.9%) | 40 (15.8%) | 1.76 (1.01-3.06) | |||
| Dominant | C/C | 144 (49%) | 110 (43.5%) | 1 | 0.230 | |
| C/A-A/A | 150 (51%) | 143 (56.5%) | 1.24 (0.88-1.76) | |||
| Recessive | C/C-C/A | 265 (90.1%) | 213 (84.2%) | 1 | 0.056 | |
| A/A | 29 (9.9%) | 40 (15.8%) | 1.67 (0.98-2.82) | |||
| Log-additive | --- | --- | --- | 1.26 (0.98-1.62) | 0.072 | |
| rs4963516 | Co-dominant | T/T | 126 (41.7%) | 138 (51.7%) | 1 | 0.023* |
| G/T | 131 (43.4%) | 104 (39%) | 0.66 (0.46-0.95) | |||
| G/G | 45 (14.9%) | 25 (9.4%) | 0.54 (0.31-0.93) | |||
| Dominant | T/T | 126 (41.7%) | 138 (51.7%) | 1 | 0.008* | |
| G/T-G/G | 176 (58.3%) | 129 (48.3%) | 0.63 (0.45-0.89) | |||
| Recessive | T/T-G/T | 257 (85.1%) | 242 (90.6%) | 1 | 0.110 | |
| G/G | 45 (14.9%) | 25 (9.4%) | 0.65 (0.38-1.10) | |||
| Log-additive | --- | --- | --- | 0.71 (0.55-0.91) | 0.110 | |
| rs749174 | Co-dominant | G/G | 201 (66.8%) | 198 (74.2%) | 1 | 0.190 |
| A/G | 91 (30.2%) | 65 (24.3%) | 0.74 (0.51-1.09) | |||
| A/A | 9 (3%) | 4 (1.5%) | 0.50 (0.15-1.66) | |||
| Dominant | G/G | 201 (66.8%) | 198 (74.2%) | 1 | 0.086 | |
| A/G-A/A | 100 (33.2%) | 69 (25.8%) | 0.72 (0.50-1.05) | |||
| Recessive | G/G-A/G | 292 (97%) | 263 (98.5%) | 1 | 0.300 | |
| A/A | 9 (3%) | 4 (1.5%) | 0.54 (0.16-1.79) | |||
| Log-additive | --- | --- | --- | 0.73 (0.52-1.03) | 0.067 |
OR =odds ratio; 95 %CI = 95 % confidence interval;
*p < 0.05 indicates statistical significance