Table 4. Multivariable linear regression analysis of MEG3 promoter methylation and expression.

MEG3 2-ΔΔCt		B	P	95% CI
MEG3_1_CpG_1	Control	3.74	0.53	−6.40	11.49
	Case	−8.68	0.09	−19.17	1.81
MEG3_1_CpG_3.4	Control	3.74	0.30	−3.96	11.44
	Case	−6.62	0.00	−10.28	−2.97
MEG3_4_CpG_9	Control	−21.60	0.01	−37.04	−6.16
	Case	−10.56	0.00	−13.54	−7.57
MEG3_5_CpG_2	Control	20.50	0.00	12.17	28.82
	Case	−6.19	0.02	−11.34	−1.05
MEG3_5_CpG_12	Control	11.27	0.18	−6.43	28.97
	Case	−3.97	0.05	−7.91	−0.03
MEG3_8_CpG_4.5	Control	6.92	0.20	−4.47	18.31
	Case	−18.80	0.04	−36.47	−1.14
MEG3_8_CpG_9	Control	13.78	0.15	−6.28	33.83
	Case	−12.68	0.02	−23.05	−2.31

P < 0.05 indicates statistical significance; 95% CI: 95% confidence interval.