Table 2B. Clinical and pathological variables associated with unfavorable disease, positive surgical margins and predominant Gleason score 4.

	Unfavorable Disease			Positive margins			Predominant Gleason 4
	No (n=316)	Yes (n=22)	p-value	No (n=302)	Yes (n=36)	p-value	No (n=276)	Yes (n=62)	p-value
Age (years)	63.5 [59 ; 67]	63.5 [59.5 ; 66]	0,904	64 [59 ; 67]	61.5 [55.5 ; 65]	0.136	63 [58 ; 67]	64.5 [60 ; 68]	0,168
PSA (ng/mL)	5.6 [4.4 ; 7.3]	5.5 [4 ; 6.3]	0,244	5.64 [4.29 ; 7.25]	5.03 [4.14 ; 7.27]	0.451	5.6 [4.4 ; 7.3]	5.6 [4.1 ; 7]	0,43
PSA density	0.12 [0.09 ; 0.15]	0.11 [0.06 ; 0.14]	0,068	0.12 [0.09 ; 0.15]	0.12 [0.09 ; 0.15]	0.925	0.12 [0.09 ; 0.15]	0.11 [0.07 ; 0.15]	0,073
Prostate Volume	48 [40 ; 55]	52 [41 ; 61.3]	0,085	49 [41 ; 55]	45 [38.5 ; 53.75]	0.102	47.5 [40 ; 55]	51.5 [41 ; 60]	0,011
Familiarity, Yes	20 (6.3)	1 (4.5)	1,000	19 (6.3)	2 (5.6)	1.000	17 (6.2)	4 (6.5)	1,000
PNI, Yes	17 (5.4)	3 (13.6)	0,132	17 (5.6)	3 (8.3)	0.458	9 (3.3)	11 (17.7)	<0.001
Nr of Positive Cores. 2	146 (46.2)	14 (63.6)	0,123	146 (48.3)	14 (38.9)	0.283	129 (46.7)	31 (50)	0,642
CIPC (%)	25 [10 ; 35]	40 [30 ; 60]	<0.001	25 [10 ; 35]	30 [20 ; 40]	0.027	20 [10 ; 30]	40 [30 ; 50]	<0.001
Positive DRE	32 (10.1)	4 (18.2)	0,273	32 (10.6)	4 (11.1)	1.000	28 (10.1)	8 (12.9)	0,525
Testosterone (ng/dL)	456 [390 ; 567]	290 [250 ; 300]	<0.001	456 [389 ; 566.25]	400.5 [290 ; 540.5]	0.0643	477 [398.3 ; 597.3]	300 [254.5 ; 502]	<0.001
Testosterone <300 ng/dL	39 (12.3)	14 (63.6)	<0.001	43 (14.2)	10 (27.8)	0.035	25 (9.1)	28 (45.2)	<0.001

CIPC: cancer involvement in positive cores; DRE: Digital rectal examination; PNI: perineural invasion; PSA: prostate-specific antigen