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. 2017 Jan 3;8(11):18456–18485. doi: 10.18632/oncotarget.14472

Figure 1. Relationship between incidence of colorectal cancer (CRC) and prevalence of DM in different parts of the world.

Figure 1

A. Global, B. Europe, North America and Australia/New Zealand, C. Latin America and Caribbean, D. Asia, E. Middle East, F. European Mediterranean countries and Israel, G. Africa. IDF 2015 data for DM (www.diabetesatlas.org/) and Globocan 2012 data for colorectal cancer (http://globocan.iarc.fr/Pages/age-specific_table_sel.aspx). Discontinuous red lines represent median values for the global population. Regional differences can be identified by the location of countries within the four quadrants. Note regional differences as well as countries that differ from others in the region. Regions are more clearly separated by CRC incidence than by DM prevalence, Europe/North America/Australia/NZ is the only high DM/high CRC region. Latin America and Caribbean is a high DM/low CRC region with the exception of Argentina and Uruguay where meat intake is high, while in the opposite extreme Mexico a is very high DM/low CRC country. In the Middle East a high prevalence of DM is not associated with high CRC incidence, unlike in European Mediterranean countries which in general behave as the rest of Europe. Korea is an example of low DM/high CRC country in Asia.