Table 3.
Allele and genotype frequencies of the five SNPs in DM/PM patients and healthy controls.
| Gene | SNP | Groups | Allele (%) | OR (95% CI) | P c | Genotype (%) | χ 2 | P c | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
| TNFSF4 | rs2205960 | T | G | TT | TG | GG | |||||
| DM | 344 (26.30) | 964 (73.70) | 1.00 (0.86–1.16) | NS | 43 (6.57) | 258 (39.45) | 353 (53.98) | 0.30 | NS | ||
| PM | 197 (27.13) | 529 (72.87) | 1.04 (0.87–1.26) | NS | 21 (5.79) | 155 (42.70) | 187 (51.52) | 0.59 | NS | ||
| DM/PM | 541 (26.60) | 1493 (73.40) | 1.01 (0.89–1.16) | NS | 64 (6.29) | 413 (40.61) | 540 (53.10) | 0.05 | NS | ||
| Controls | 674 (26.33) | 1886 (73.67) | 78 (6.09) | 518 (40.47) | 684 (53.44) | ||||||
|
| |||||||||||
| TNFSF4 | rs844644 | C | A | CC | CA | AA | |||||
| DM | 601 (45.95) | 707 (54.05) | 1.10 (0.96–1.26) | 0.850 | 129 (19.72) | 343 (52.45) | 182 (27.83) | 3.17 | NS | ||
| PM | 325 (44.77) | 401 (55.23) | 1.05 (0.89–1.24) | NS | 67 (18.46) | 191 (52.62) | 105 (28.93) | 1.40 | NS | ||
| DM/PM | 926 (45.53) | 1108 (54.47) | 1.08 (0.96–1.21) | 0.995 | 196 (19.27) | 534 (52.51) | 287 (28.22) | 3.53 | 0.855 | ||
| Controls | 1116 (43.63) | 1442 (56.37) | 243 (19.00) | 630 (49.26) | 406 (31.74) | ||||||
|
| |||||||||||
| TNFSF4 | rs844648 | A | G | AA | AG | GG | |||||
| DM | 607 (46.41) | 701 (53.59) | 1.08 (0.94–1.23) | NS | 129 (19.72) | 349 (53.36) | 176 (26.91) | 5.53 | 0.315 | ||
| PM | 332 (45.73) | 394 (54.27) | 1.05 (0.89–1.24) | NS | 68 (18.73) | 196 (53.99) | 99 (27.27) | 4.07 | 0.655 | ||
| DM/PM | 939 (46.17) | 1095 (53.83) | 1.07 (0.95–1.20) | NS | 197 (19.37) | 545 (53.59) | 275 (27.04) | 7.50 | 0.115 | ||
| Controls | 1141 (44.57) | 1419 (55.43) | 263 (20.55) | 615 (48.05) | 402 (31.41) | ||||||
|
| |||||||||||
| ANKRD55 | rs6859219 | A | C | AA | AC | CC | |||||
| DM | 5 (0.38) | 1303 (99.62) | 0.75 (0.27–2.11) | NS | 0 (0.00) | 5 (0.76) | 649 (99.24) | NA | NA | ||
| PM | 5 (0.69) | 721 (99.31) | 1.36 (0.48–3.82) | NS | 0 (0.00) | 5 (1.38) | 358 (98.62) | NA | NA | ||
| DM/PM | 10 (0.49) | 2024 (99.51) | 0.97 (0.42–2.21) | NS | 0 (0.00) | 10 (0.98) | 1007 (99.02) | NA | NA | ||
| Controls | 13 (0.51) | 2547 (99.49) | 0 (0.00) | 13 (1.02) | 1267 (98.98) | ||||||
|
| |||||||||||
| ANKRD55 | rs7731626 | A | G | AA | AG | GG | |||||
| DM | 99 (7.57) | 1209 (92.43) | 0.76 (0.59–0.96) | 0.120 | 5 (0.76) | 89 (13.61) | 560 (85.63) | 4.93 | 0.425 | ||
| PM | 58 (7.99) | 668 (92.01) | 0.80 (0.60–1.08) | 0.735 | 1 (0.28) | 56 (15.43) | 306 (84.30) | NA | NA | ||
| DM/PM | 157 (7.72) | 1877 (92.28) | 0.77 (0.63–0.95) | 0.075 | 6 (0.59) | 145 (14.26) | 866 (85.15) | 6.14 | 0.23 | ||
| Controls | 250 (9.77) | 2310 (90.23) | 16 (1.25) | 218 (17.03) | 1046 (81.72) | ||||||
SNPs = single nucleotide polymorphisms; DM = dermatomyositis; PM = polymyositis; OR = odds ratio; CI = confidence interval; Pc = P value corrected by Bonferroni method; χ2 = Chi-square test; NS = not significant; NA = not available.