Table 3.

Diagnostic Tests and Their Role in the Various Phases of Evaluation and Management of Cardiac Amyloidosis

Imaging and biomarkers of Cardiac Amyloidosis
Phase of work-up	ECHO	MRI*	“Bone tracers” scintigraphy	BNP
Suspicion	+++	++	+/− (TTR)	++
Early diagnosis	+/−	++	++ (TTR)	+/−
Definite diagnosis	+/−	+/−	+++	+/−
Etiologic diagnosis	+/−	+/−	+++ (TTR)	-
Functional evaluation	+++	++	+ (MIBG)	+/−
Prognostic stratification	++	+	+	+++
Amyloid burden	-	++	+/−	-
Response to therapy	+/	+/−	+/−	+++ (AL)

^*T1 native, LGE ECV, TTR – useful for TTR amyloid, MIBG - iodine-131-meta-iodobenzylguanidine.

+++ = very useful, recommended, ++= useful, to be considered, += possibly useful

+/− = role uncertain, − = not useful.