Table 3.

Serum cholesterol concentration (mmol/L) after two 4-week periods of coffee consumption (week 3 – 7 and week 10 – 14) for APOE ε2-positive (n = 13) and APOE ε2-negative (n = 108) individuals

	APOE ε2-positive	APOE ε2-negative	p
	n = 13	n = 107/103 a
First trial period
week 3	4.49 (0.71)	5.05 (0.90)
week 7	4.52 (0.71)	5.34 (0.93)
diff week 3–7	0.03 (0.57)	0.29 (0.57)	0.09 b
p (diff 3–7)	0.70	<0.0001 c
Second trial period
week 10	4.34 (0.64)	4.95 (0.89)
week 14	4.54 (0.84)	5.09 (0.85)
diff week 10–14	0.20 (0.47)	0.14 (0.59)	0.37 b
p (diff 10–14)	0.15	0.009 c

^a 107 participants in the first trial period and 103 participants in the second trial period

^b No significant difference between 2-positive and 2-negative in differences between week 3–7 or week 10–14, Wilcoxon rank sum test

^c Significant difference between week 0–3 and week 7–10 for the APOE ε2-negative group, Signed rank test