In vivo efficacy of HIFU hyperthermia and heat shock-targeted polymer-docetaxel. A) Tumor volume over 30 days when injected with saline, free docetaxel (free DOC), untargeted polymer-docetaxel (polymer-DOC), or heat shock-targeted polymer-docetaxel (HS polymer-DOC) with and without HIFU hyperthermia. B) Animal weights when injected with saline, free DOC, polymer-DOC, or HS polymer-DOC. C) Treatment groups with hyperthermia. D) Treatment groups without hyperthermia. For each treatment group n=6. * And ** indicate statistical significance compared to saline control.