Table 1. Demographics of the subjects.
| CN (n=20) | EMCI (n=17) | LMCI (n=20) | AD (n=20) | Post-hoc comparisons | |
|---|---|---|---|---|---|
| Female | 11 (55.0) | 4 (23.5) | 6 (30.0) | 10 (50.0) | |
| Age (years) | 69.9±3.3 | 67.8±5.3 | 69.2±4.8 | 68.3±4.3 | |
| Education (years) | 16.6±2.8 | 16.2±2.6 | 16.1±2.7 | 15.7±2.4 | |
| GCDR | 0.0 | 0.5 | 0.5 | 0.8±0.3 | CN<EMCI=LMCI<AD |
| MMSE | 28.9±1.1 | 28.4±1.4 | 27.2±1.9 | 23.5±1.9 | CN=EMCI=LMCI<AD |
| MADAS-Cog* | 7.3±3.1 | 14.7±6.7 | 20.4±6.1 | 28.3±9.8 | CN<EMCI<LMCI<AD |
| Logical Memory I: immediate recall | 13.3±3.0 | 10.5±2.3 | 5.8±3.1 | 3.5±2.0 | CN<EMCI<LMCI<AD |
| Logical Memory II: delayed recall | 11.8±3.3 | 9.2±1.4 | 2.5±2.9 | 1.6±2.0 | CN<EMCI<LMCI=AD |
| Florbetapir+* | 3 (17.6) | 5 (31.3) | 14 (82.4) | 20 (100.0) | CN=EMCI<LMCI<AD |
| Aβ42 (µg/mL)* | 210.9±54.3 | 186.8±56.5 | 161.8±55.3 | 124.1±25.7 | CN=EMCI<LMCI<AD |
| p-tau (µg/mL)* | 29.7±9.2 | 36.2±31.7 | 59.1±30.1 | 76.0±40.0 | CN=EMCI<LMCI=AD |
Data are n (%) or mean±SD values. There were no gender, age, or education intergroup differences. Two-sample t-tests (p<0.01) between groups were used for post-hoc analysis. MMSE scores in CN, EMCI, and LMCI did not show significant differences. Logical Memory II: delayed recall in LMCI and AD did not show a significant difference. Florbetapir and CSF biomarkers in CN and EMCI did not show a significant difference.
*Missing data: (MADAS-Cog) 3 CN, 1 EMCI, 2 LMCI, 1 AD. (Florbetapir) 3 CN, 1 EMCI, 3 LMCI. (CSF biomarkers) 7 CN, 2 EMCI, 3 LMCI, 3 AD.
AD: Alzheimer's disease, CN: cognitive normal, EMCI: early mild cognitive impairment, GCDR: global Clinical Dementia Rating, LMCI: late mild cognitive impairment, MADAS-Cog: Modified Alzheimers Disease Assessment Scale-Cognitive subscale, MMSE: Mini Mental State Examination.