Table 1. Baseline characteristics by total SVD scores.
| SVD score | Total (n=1,096) | 0 (n=550) | 1 (n=252) | 2 (n=107) | 3 (n=113) | 4 (n=74) | p value |
|---|---|---|---|---|---|---|---|
| Demographic data | |||||||
| Sex, male | 675 (61.5) | 341 (62.0) | 164 (65.1) | 57 (53.3) | 68 (60.2) | 44 (59.5) | 0.320 |
| Age, years | 66.3±11.8 | 63.3±12.2 | 67.0±10.5 | 71.4±10.8 | 69.6±10.6 | 73.1±10.0 | <0.001 |
| Risk factors | |||||||
| Hypertension | 828 (75.5) | 363 (66.0) | 198 (78.6) | 95 (88.8) | 104 (92.0) | 68 (91.9) | <0.001 |
| Diabetes mellitus | 341 (31.1) | 149 (27.1) | 90 (35.7) | 36 (33.6) | 41 (36.3) | 25 (33.8) | 0.071 |
| Hyperlipidemia | 116 (10.6) | 63 (11.5) | 25 (9.9) | 4 (3.7) | 18 (15.9) | 6 (8.1) | 0.045 |
| Previous stroke | 200 (18.2) | 72 (13.1) | 45 (17.9) | 24 (22.4) | 35 (31.0) | 24 (32.4) | <0.001 |
| Smoking | 256 (23.4) | 145 (26.4) | 58 (23.0) | 17 (15.9) | 28 (24.8) | 8 (10.8) | 0.012 |
| Coronary artery disease | 209 (19.1) | 86 (15.6) | 59 (23.4) | 20 (18.7) | 25 (22.1) | 19 (25.7) | 0.039 |
| Metabolic syndrome | 512 (46.7) | 243 (44.2) | 124 (49.2) | 53 (49.5) | 55 (48.7) | 37 (50.0) | 0.578 |
| Prior medication | |||||||
| Anti-platelet | 401 (36.6) | 169 (30.7) | 99 (39.3) | 48 (44.9) | 55 (48.7) | 30 (40.5) | 0.001 |
| Anti-coagulant | 62 (5.7) | 34 (6.2) | 15 (6.0) | 2 (1.9) | 5 (4.4) | 6 (8.1) | 0.360 |
| Lipid-lowering agents | 213 (19.4) | 101 (18.4) | 47 (18.7) | 23 (21.5) | 24 (21.2) | 18 (24.3) | 0.707 |
| Laboratory findings | |||||||
| Estimate GFR, mL/min/1.73 m2 | 80.5±27.2 | 85.8±26.1 | 78.7±24.4 | 72.1±29.4 | 73.2±29.6 | 70.1±28.1 | <0.001 |
| WBC count /103 | 8.4±3.1 | 8.5±3.3 | 8.4±3.0 | 8.3±3.0 | 8.1±3.1 | 7.8±2.0 | 0.523 |
| Hemoglobin, mg/dL | 13.7±1.8 | 13.8±1.8 | 13.7±1.8 | 13.6±1.5 | 13.4±2.2 | 13.5±2.0 | 0.389 |
| Stroke classification | 0.618 | ||||||
| Large artery atherosclerosis | 206 (18.8) | 107 (19.5) | 42 (16.7) | 18 (16.8) | 20 (17.7) | 19 (25.7) | |
| Lacune | 115 (10.5) | 52 (9.5) | 31 (12.3) | 10 (9.3) | 11 (9.7) | 11 (14.9) | |
| Cardioembolism | 285 (26.0) | 157 (28.5) | 56 (22.2) | 27 (25.2) | 27 (23.9) | 18 (24.3) | |
| Multiple causes | 219 (20.0) | 106 (19.3) | 55 (21.8) | 20 (18.7) | 26 (23.0) | 12 (16.2) | |
| Negative evaluation | 271 (24.7) | 128 (23.3) | 68 (27.0) | 32 (29.9) | 29 (25.7) | 14 (18.9) | |
| Thrombolytic or endovascular reperfusion therapy | 113 (10.3) | 69 (12.5) | 25 (9.9) | 7 (6.5) | 7 (6.2) | 5 (6.8) | 0.102 |
| NIHSS score, median (IQR) | 3 (1–7) | 3 (1–8) | 3 (1–7) | 3 (1–9) | 3 (2–5) | 3 (2–6) | 0.722 |
Values are number (%), mean±SD or median (interquartile range).
GFR: glomerular filtration rate, IQR: interquartile range, NIHSS: National Institutes of Health Stroke Scale, SVD: small-vessel disease, WBC: white blood cell.