Fig. 4.

Drug interaction between ezetimibe and warfarin in Wistar rats.

(A) Prothrombin time and (B) hepatic vitamin K₁ concentrations of Wistar rats after 1 week of daily oral co-administration of warfarin (0.2 mg/kg per day), ezetimibe (1 mg/kg per day), and vitamin K₁ (1 µg/200 g body weight per day). Data are shown as the mean ± SEM (n = 6–13). **Significantly different by Mann-Whitney test with Bonferroni-Holm correction (p < 0.01). *Significantly different by Mann-Whitney test with Bonferroni-Holm correction (p < 0.05). (Modified and cited from reference 42).