Table 1.

OTUs that Were Significantly Changed in Old SPF and TNF KO Mice

Increased
Family	Genus	Number of OTUs (WT)a	Old > Young (WT)	Old > Young (TNF KO)	Number of OTUs (TNF KO)
Ruminococcaceae	Ruminococcus	6	∗∗∗∗	NS	7
Lachnospiraceae	Clostridium	34	∗∗∗∗	∗∗b	34
Ruminococcaceae	Clostridium	14	∗∗∗∗	NS	16
Prevotellaceae	Prevotella	39	∗∗	∗∗	44
Erysipelotrichaceae	Allobaculum	54	∗∗∗∗	∗	60
Lachnospiraceae	many identified	354	∗	∗b	343
Bifidobacteriaceae	Bifidobacterium	17	∗∗∗	∗∗	17
Ruminococcaceae	Oscillospira	54	∗∗∗∗	NS	56
Lactobacillaceae	Lactobacillus	53	∗∗∗	∗∗∗∗b	57
Bacteroidaceae	Bacteroides	52	∗∗	∗∗∗	71
Coriobacteriaceae	Adlercreutzia	22	∗∗∗	NS	23
Peptococcaceae	not identified	14	∗	NS	15
Catabacteriaceae	not identified	51	∗∗∗∗	∗∗b	65
Coriobacteriaceae	not identified	14	∗∗∗	NS	14
Decreased
Family	Genus	Number of OTUs (WT)	Old < Young (WT)	Old < Young (TNF KO)	Number of OTUs (TNF KO)
Rikenellaceae	Alistipes	48	∗∗	NS	52
Verrucomicrobiaceae	Akkermansia	41	∗∗∗∗	∗c	49
Lachnospiraceae	Blautia	11	∗∗∗∗	∗c	10

^∗p < 0.05, ^∗∗p < 0.005, ^∗∗∗p < 0.0005, and ^∗∗∗∗p < 0.0001; NS, not significant.

^aNumber of OTUs is the number of OTUs found in the samples that are attributed to the family or genus.

^bOTUs that were significantly decreased in old TNF KO mice.

^cOTUs that were significantly increased in old TNF KO mice.