Table 2.
OTUs Altered by Anti-TNF Treatment in Old Mice
| Increased | |||
|---|---|---|---|
| Family | Genus | Old SPF > Young SPF | Decreased by Anti-TNF Treatment |
| Erysipelotrichaceae | not identified | ∗∗∗∗ | NS |
| Ruminococcaceae | Ruminococcus | ∗∗∗∗ | NS |
| Lachnospiraceae | Clostridium | ∗∗∗∗ | NS |
| Ruminococcaceae | Clostridium | ∗∗∗∗ | NS |
| Prevotellaceae | Prevotella | ∗∗ | NS |
| Erysipelotrichaceae | Allobaculum | ∗∗∗∗ | NS |
| Lachnospiraceae | many identified | ∗ | NS |
| Bifidobacteriaceae | Bifidobacterium | ∗∗∗ | NS |
| Ruminococcaceae | Oscillospira | ∗∗∗∗ | NS |
| Lactobacillaceae | Lactobacillus | ∗∗∗ | NS |
| Bacteroidaceae | Bacteroides | ∗∗ | ∗ |
| Coriobacteriaceae | Adlercreutzia | ∗∗∗ | ∗ |
| Peptococcaceae | not identified | ∗ | ∗∗ |
| Catabacteriaceae | not identified | ∗∗∗∗ | ∗ (increased) |
| Coriobacteriaceae | not identified | ∗∗∗ | ∗ |
| Ruminococcaceae | Subdoligranulum | NS | ∗ |
| Decreased | |||
| Family | Genus | Old < Young | Increased by Anti-TNF Treatment |
| Rikenellaceae | Alistipes | ∗∗ | NS |
| Verrucomicrobiaceae | Akkermansia | ∗∗∗∗ | NS |
| Lachnospiraceae | Blautia | ∗∗∗∗ | NS |
| Lachnospiraceae | Roseburia | NS | ∗ |
| Eubacteriaceae | Anaerofustis | NS | ∗ |
Families that are higher in old SPF mice are listed. Those that are decreased by anti-TNF treatment in old mice are labeled with an asterisk. ∗p < 0.05, ∗∗p < 0.005, ∗∗∗p < 0.0005, and ∗∗∗∗p < 0.0001; NS, not significant.