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. 2017 Mar 31;5(7):e13163. doi: 10.14814/phy2.13163

Figure 2.

Figure 2

MSS mainly induces a TH17 polarized immune response. (A) Severity of the inflammatory response following exposure to 3 μg versus 100 μg of MSS was quantified using total broncho‐alveolar lavage (BAL) count and differential count. Results are representative of at least three separate experiments; n = 3–6 mice/group. * = P ˂ 0.05. (B) Polarity of the effector response evaluated as number and the % of CD4+ cells expressing IFNg, IL‐13 or IL‐17A. (C) MSS‐specific IgG1 and IgG2a production was measured from serum using ELISA. Results were pooled from two experiments; n = 6–10 mice/group. † = P ˂ 0.05 with multi‐comparison test. Using the Flexivent Apparatus, (D) airway resistance (Rrs) was evaluated in mice exposed to 3 μg or 100 μg MSS. Results were pooled from two experiments; n = 6–12 mice/group. * = P ˂ 0.05.