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. 2017 Apr 10;5(7):e13213. doi: 10.14814/phy2.13213

Figure 6.

Figure 6

Selective cholinergic agonist (PNU‐282,987) blunts the rise in blood pressure and reduces from renal injury in female SLE mice: (A) Mean arterial pressure measured in control and SLE mice administered vehicle or PNU‐282,987 for 28 days. n = 2–4 animals/group; (B) Proteinuria as measured by Albustix (“grades” calculated as described in the methods) in control and SLE mice administered vehicle or PNU‐282,987 for 28 days. n = 3–5 animals/group; (C) Glomerulosclerosis index in PAS‐stained paraffin embedded kidneys of control and SLE mice administered vehicle or PNU‐292,987 for 28 consecutive days. n = 3–4/group; (D) Representative pictures of PAS‐stained kidneys of control and SLE mice administered vehicle or PNU‐292,987 for 28 consecutive days. SLE, Systemic lupus erythematosus; PAS, periodic acid‐Schiff.