Figure 2.

Systolic pulmonary artery pressure (SPAP) breathing room air (Normoxia) and after 10 min of hypoxia (Acute Hypoxia; end tidal PO₂ 50 mmHg) in a patient with PHD2 mutation, compared with previously published (Smith et al. 2006, 2008a) responses in normal control participants (n = 8), patients with Chuvash polycythemia (n = 3), healthy volunteers immediately after prolonged hypoxia (end tidal PO₂ 55 mmHg for 8 h; n = 8), and healthy volunteers immediately after infusion of the iron chelator desferrioxamine mesylate (4 g per 70 kg over 8 h; n = 8). Symbols show mean ± SEM.