Table 4.
Demographics, right heart catheterization and RV hemodynamic data when reclassifying patients with CTED or CTEPH by Ees/Eamax sw determined from an animal model
| Ees/Ea ≥ 0.68 (n = 11) | Ees/Ea < 0.68 (n = 9) | P‐value | |
|---|---|---|---|
| Demographics | |||
| CTED, N (%) | 8 (72.7) | 2 (27.3) | 0.072 |
| CTEPH, N (%) | 3 (22.2) | 7 (77.7) | 0.073 |
| Age, years | 55 ± 16 | 50 ± 16 | 0.516 |
| Male sex, N (%) | 5 (45.4) | 5 (55.6) | 0.653 |
| BMI, kg/m2 | 30.9 ± 7.4 | 29.1 ± 4.9 | 0.804 |
| 6MWD, m | 380 ± 81 | 364 ± 137 | 0.747 |
| WHO class (II/III) | 11 (100.0) | 9 (100.0) | 1.000 |
| Right heart catheter | |||
| mPAP, mmHg | 22.8 ± 8.0 | 37.1 ± 12.5 | 0.006 |
| Systolic PAP, mmHg | 38.8 ± 17.1 | 60.9 ± 23.5 | 0.026 |
| Diastolic PAP, mmHg | 12.4 ± 6.0 | 22.9 ± 9.1 | 0.006 |
| mRAP, mmHg | 7.1 ± 4.7 | 6.7 ± 3.0 | 0.817 |
| PCWP, mmHg | 10.8 ± 5.8 | 8.0 ± 2.2 | 0.144 |
| RV EDP, mmHg | 7.6 ± 4.5 | 8.3 ± 3.5 | 0.709 |
| SvO2, % | 74.5 ± 4.7 | 71.0 ± 6.0 | 0.120 |
| CO, L/min | 5.3 ± 1.3 | 4.6 ± 1.0 | 0.217 |
| CI, L/min/m2 | 2.7 ± 0.3 | 2.3 ± 0.5 | 0.082 |
| PVR, dyne/sec/cm5 | 181 ± 78 | 554 ± 250 | 0.003 |
| RV hemodynamics | |||
| Heart rate, BPM | 65 ± 11 | 75 ± 10 | 0.04 |
| SW, mmHg.mL | 1683 ± 663 | 1743 ± 755 | 0.853 |
| CO, L/min | 5.6 ± 1.2 | 4.4 ± 0.8 | 0.024 |
| ESP, mmHg | 36.7 ± 11.6 | 68.1 ± 16.7 | <0.001 |
| EDP, mmHg | 10.2 ± 3.8 | 13.5 ± 4.7 | 0.103 |
| ESV, mL | 114.0 ± 36.3 | 78.6 ± 31.4 | 0.034 |
| EDV, mL | 156.1 ± 35.5 | 107.0 ± 37.1 | 0.007 |
| SV, mL | 87.7 ± 22.1 | 60.1 ± 16.5 | 0.006 |
| EF, % | 53.3 ± 9.8 | 54.0 ± 8.8 | 0.875 |
| dP/dtmax, mmHg/sec | 385 ± 114 | 475 ± 190 | 0.173 |
| dP/dtmin, mmHg/sec | ‐358 ± 136 | ‐612 ± 183 | 0.003 |
| Ea, mmHg/mL | 0.42 ± 0.10 | 1.22 ± 0.43 | <0.001 |
| Tau, msec | 67.1 ± 13.7 | 60.8 ± 19.2 | 0.418 |
| Ees/Ea | 2.38 ± 1.49 | 0.45 ± 0.14 | <0.001 |
Values are mean ± SD or n (%).
CTED, chronic thromboembolic disease; CTEPH, chronic thromboembolic pulmonary hypertension; BMI, body mass index; 6MWD, 6 min walking distance; WHO Class, world health organisation classification; mPAP, mean pulmonary arterial pressure; mRAP, mean right atrial pressure; PCWP, pulmonary capillary wedge pressure; RV EDP, right ventricular end‐diastolic pressure; SvO2, mixed venous oxygen saturations; CO, cardiac output; CI, cardiac index; PVR, pulmonary vascular resistance; SW, stroke work; ESP, end‐systolic pressure; EDP, end‐diastolic pressure; ESV, end‐systolic volume; EDV, end‐diastolic volume; SV, stroke volume; EF, ejection fraction; dP/dtmax, maximum rate of isovolumic contraction; dP/dtmin, maximum rate of isovolumic relaxation; Ea, effective arterial Elastance; Tau, time constant of diastolic relaxation; Ees/Ea, single‐beat ventriculo‐arterial coupling ratio.