TABLE 1.
Residue | Mutation | Domain | Reasoning |
---|---|---|---|
Tyr-495 | Phe | Juxtamembrane | Phosphoproteomic screen |
Lys-565 | Arg | Kinase | DB-acyl-ATP screen |
Lys-663 | Arg | Kinase | DB-acyl-ATP screen |
Lys-684 | Arg | Kinase | DB-acyl-ATP screen |
Thr-696 | Ala/Asp | Kinase | Phosphoproteomic screen |
Lys-699 | Arg | Kinase | DB-acyl-ATP screen |
Ser-701 | Ala/Asp | Kinase | Phosphoproteomic screen |
Ser-871 | Ala/Asp | C terminus | Phosphoproteomic screen |
Ser-877 | Ala/Asp | C terminus | Phosphoproteomic screen |